Alexion Pharmaceuticals Inc.'s acquisition of Achillion Pharmaceuticals Inc. will add two clinical-stage drugs that will build on Alexion's own expertise in complement alternative pathway-mediated rare diseases. Achillion is developing oral small molecule Factor D inhibitors for diseases like paroxysmal nocturnal hemoglobinuria (PNH), where Alexion is the current market leader with its C5 inhibitor Soliris (eculizumab) and second-generation drug Ultomiris (ravulizumab).
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