AstraZeneca's Calquence Steps Up in First-Line CLL

Full Results Of First-Line Calquence Use In CLL

A PFS benefit and favorable tolerability profile associated with AstraZeneca’s BTK inhibitor acalabrutinib used first-line in CLL, when given alone or combined with obinutuzumab, may serve it well against entrenched competitors and BTK inhibitors in clinical development.

Horse_Racing
The race is on to gain market share in CLL patients • Source: Shutterstock

Initial thoughts on the full results of the ELEVATE TN study of AstraZeneca PLC’s Bruton’s tyrosine kinase (BTK) inhibitor, Calquence (acalabrutinib), administered alone or with the anti-CD20 MAb, obinutuzumab (Roche/Genentech Inc.’s Gazyva), as first-line therapy for chronic lymphocytic leukemia, have alighted on Calquence’s favorable tolerability profile, and the intense competitive pressure likely to arise in the therapeutic segment from a number of BTK inhibitors currently in development.

Such pressures are now also expected to come from Merck & Co. Inc., which announced its intentions earlier this...

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

  • Start your 7-day free trial
  • Explore trusted news, analysis, and insights
  • Access comprehensive global coverage
  • Enjoy instant access – no credit card required

More from Anticancer

More from Therapy Areas