Bispecific antibodies that are designed to target cancer cells and engage T-cells gained momentum at the recent American Society of Hematology (ASH) conference, prompting the question of whether these candidates could steal market share from chimeric antigen receptor T-cell (CAR-T) cell therapies that have generated a lot of excitement over the past few years.
Bispecifics Could Be A Threat To CAR-Ts, But Efficacy May Trump Convenience
T-cell-engaging bispecific antibodies emerged at ASH as viable competitors for autologous T-cell therapies, but while their off-the-shelf availability is intriguing, it may be too early to say if their safety and efficacy beats CAR-Ts.
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