Another Alzheimer's Setback As Roche And Lilly Drugs Fail

Fresh Disappointment For Amyloid Hypothesis

As Biogen moves to file its controversial amyloid drug aducanumab for approval in the US, two similar investigational Alzheimer's drugs – Eli Lilly's solanezumab and Roche's gantenerumab – did not slow memory loss or cognitive decline in a rare, inherited form of the disease.

Alzheimers_Cells
Amyloid Hypothesis Under The Microscope Again • Source: Shutterstock

The theory that beta-amyloid (Abeta) is the main cause of Alzheimer's has taken yet another bashing after a closely watched trial evaluating Eli Lilly & Co.'s solanezumab and Roche's gantenerumab in people in the early stages of a rare, inherited form of the disease yielded disappointing results.

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