Recent entrants, including some big pharma players, threaten to make the fibroblast growth factor (FGF) analog class another crowded field of clinical development for non-alcoholic steatohepatitis, but 89bio Inc. thinks its mid-stage FGF21 analog could prove best in class with less frequent dosing than a Phase II FGF21 candidate at Bristol-Myers Squibb Co. and offer a better safety profile than NGM Biopharmaceuticals Inc.’s Phase IIb FGF19 analog.
89Bio’s NASH Hopes Hang On Demonstrating Best-In-Class FGF21 Profile
89Bio thinks its Phase II FGF21 analog could prove best-in-class in NASH due to a longer half-life than Bristol’s pegbelfermin, and avoid the LDL-increasing effects seen with NGM’s FGF19 analog.
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