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New Mechanisms: Cardior’s Non-Coding RNA Therapeutic For Heart Failure

MicroRNAs Also Of Interest To Other Biotechs

 
• By John Davis

Germany’s Cardior is conducting clinical studies with an antisense oligonucleotide which inhibits a cellular microRNA believed to be involved in the pathology of heart failure, and is attracting attention from other pharma companies interested in the potential of this new mechanism of action.  

MicroRNA
A micro-RNA molecule. • Source: Shutterstock

The growing development effort into evaluating RNA as a target for novel therapeutics could lead to a novel type of therapy to treat heart failure, according to the clinical-stage German biotech, Cardior Pharmaceuticals GmbH.

Cardior has started a Phase Ib clinical study with its lead compound, CDR132L, an antisense oligonucleotide that inhibits a non-coding...

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