Merck Is Counting On Keytruda To Establish Its Anti-TIGIT Drug

Vibostolimab is less advanced than Roche’s competing tiragolumab, but Merck thinks the combo of its anti-TIGIT and Keytruda will offer a better therapeutic profile.

RAHWAY, NJ - JULY 17: A sign at the entrance to a Merck plant in Rahway, New Jersey on July 17, 2017. Merck is an American pharmaceutical company.
Merck thinks its anti-TIGIT candidate will benefit from combination with Keytruda

Coming out of the 2020 American Society of Clinical Oncology meeting, Merck & Co. Inc. is getting some credit for the potential of its TIGIT inhibitor vibostolimab, which it is studying in combination with other checkpoint inhibitors – Keytruda and a CTLA-4 inhibitor – in non-small cell lung cancer and melanoma. At least one analyst sees this candidate leading the space along with Roche’s tiragolumab, and presumably ahead of at least six other firms with anti-TIGIT agents in clinical development.

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