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Biohaven Taking Troriluzole Into Phase III OCD Study Despite Phase II/III Miss

 
• By Mandy Jackson

After a prior failure in treating anxiety, the company believes the glutamate modulator showed signs of efficacy in obsessive-compulsive disorder that are worth pursuing, including at a higher dose.

OCD Obsessive Compulsive Disorder written in notebook on white table
Troriluzole was numerically but not statistically better than placebo • Source: Shutterstock

Biohaven Pharmaceutical Holding Co. Ltd. reported Phase II/III results for the glutamate modulator troriluzole in obsessive-compulsive disorder (OCD) on 24 June that did not meet the clinical trial’s primary endpoint, but said the improvements versus placebo – particularly in patients with severe OCD – justify a Phase III clinical trial that will include a higher dose of the drug.

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