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DAPA-CKD Data Put AstraZeneca’s Farxiga Out Front

 
• By Alexandra Shimmings

A 39% relative risk reduction in the primary endpoint for the DAPA-CKD study and a 31% reduction in all-cause mortality prime Farxiga for a new chronic kidney disease indication following filings due in the next few months.    

Human kidney on scientific background. 3d illustration
• Source: Shutterstock

AstraZeneca PLC is set to make regulatory filings worldwide in the coming months to expand the label for its SGLT2 inhibitor Farxiga (dapagliflozin) to include patients with chronic kidney disease, both with and without type 2 diabetes, on the basis of the data from the DAPA-CKD study.

DAPA-CKD was stopped early in March because of “overwhelming efficacy” and in July, AstraZeneca revealed that it had shown a significant and clinically meaningful effect on its primary endpoint of...

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