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ESMO: Sanofi/Regeneron’s Latecomer Anti-PD-1 Libtayo Looking Likely In NSCLC

Libtayo Shows 32% OS Benefit In EMPOWER-Lung 1

 
• By Alexandra Shimmings

Sanofi/Regeneron’s anti-PD-1 product Libtayo may be late to the NSCLC party but strong data from EMPOWER-Lung 1 suggest it could gain traction in the space, especially in patients with high PD-L1 expression levels.  

lung illustration
• Source: Shutterstock

Sanofi/Regeneron Pharmaceuticals, Inc.’s anti-PD1 product Libtayo (cemiplimab) should find a place in the first-line treatment of locally advanced or metastatic non-small cell lung cancer despite its late entry to the market, the full data from its Phase III EMPOWER-Lung 1 study suggest.

The results, presented during a late-breaker session at the European Society for Medical Oncology meeting on 21 September, show the product reduced the risk of death by 32% compared with platinum doublet chemotherapy, and by 43% in a prespecified analysis of patients with confirmed PD-L1 expression of >/=50%, an underserved population

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