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Lilly Sees Positive Results With Next-Gen Alzheimer’s Drug Donanemab

Patients Saw Less Cognitive, Functional Decline In Phase II Trial

 
• By Mandy Jackson

Lilly reported positive results from a Phase II pivotal trial of donanemab, which targets a modified form of beta-amyloid called N3pG, and has a second pivotal Phase II study under way.

vector illustration of colorful brain
Donanemab also rapidly cleared amyloid from Alzheimer's patients' brains • Source: Shutterstock

Eli Lilly and Company has long said that it has not given up on the hypothesis that a drug clearing amyloid plaques from the brains of Alzheimer’s patients can slow progression of the disease, even after the high-profile Phase III failure of solanezumab four years ago. Now, the company has data showing that thinking and function declined more slowly among patients treated with its next-generation anti-amyloid antibody donanemab than in those who received a placebo.

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