AACR Round-Up: BMS, Lilly, iTeos, Affimed, Treovir, Revolution And Cardiff

Immuno-Oncology Highlights Include TIGIT, NK Cell Booster & HSV Oncolytic

iTeos presents early anti-TIGIT results, Affimed reports 100% response rate in Hodgkin lymphoma, Treovir will start a pivotal Phase II after Phase I pediatric glioma study, updates in KRAS-mutated cancers from Revolution Medicines and Cardiff Oncology, plus Opdivo plus chemo shows complete responses in neoadjuvant lung cancer and Lilly’s Retevmo is active in additional tumors.

Cancer cell 3D — Immunotherapy boosters, an oncolytic HSV therapy and other novel therapies were presented at AACR • Source: Shutterstock

Elaborating on top-line data it announced last October, Bristol Myers Squibb Company reported on 10 April that Opdivo can yield pathologic complete response in pre-surgical non-small cell lung cancer patients, the first time an immunotherapy has demonstrated pathological response in a Phase III study in neoadjuvant lung cancer.

The pharma outlined the early data from its CheckMate-816 trial in October saying Opdivo (nivolumab) plus chemotherapy bested chemotherapy alone...