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Amgen’s Sotorasib Updates Raise New Questions For KRAS Program

Lower Dose Being Tested Against Higher Dose Under FDA Review

 
• By Mandy Jackson

The company provided updates on the timing of some data from its extensive clinical program for its KRAS G12C inhibitor Lumakras, but not for certain high-profile combinations.

Stack of question marks on wood table
Amgen's Lumakras updates raised new questions about the KRAS G12C inhibitor • Source: Alamy

Questions about Amgen, Inc.’s KRAS G12C inhibitor sotorasib – newly branded Lumakras – are never in short supply, but the company’s updates regarding the oral cancer drug as part of its first quarter earnings reporting on 27 April raised more questions than it answered.

The biggest question of all is why Amgen has initiated a Phase II study testing a 240mg once-daily dose versus...

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