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Keytruda Adjuvant Kidney Cancer Data Cement The Future Of IO

“Practice Changing” KEYNOTE-564 Data Presented At ASCO Plenary

 
• By Alaric DeArment

The data illustrate the growing importance of adjuvant settings of solid tumors for PD-1/PD-L1 inhibitors, which could make up more than one-quarter of their sales in 2025.

Human kidney on scientific background. 3d illustration
Merck & Co. presents "practice changing" data on Keytruda in adjuvant renal cell carcinoma • Source: Shutterstock

The KEYNOTE-564 study supporting use of Merck & Co., Inc.’s Keytruda(pembrolizumab) in adjuvant renal cell carcinoma (RCC), and likely another first-to-market advantage for the PD-1 inhibitor, is an important advance as checkpoint inhibitor immuno-oncology shifts to earlier use in adjuvant settings in various cancers.

The Kenilworth, NJ-based drug maker presented positive data from the Phase III KEYNOTE-564 study comparing Keytruda with placebo in adjuvant RCC at the 6 June plenary session of the American...

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More from ASCO

ASCO Preview: Data From Regeneron, J&J/Legend And Others In Hematology

 
• By Alaric DeArment

With the American Society of Clinical Oncology meeting kicking off on 30 May, Scrip will follow the latest in blood cancers, including Regeneron’s linvoseltamab in multiple myeloma and Merck’s ADC zilovertamab vedotin in DLBCL.

Merus Bispecific Impresses In Head And Neck Cancer

 
• By Andrew McConaghie

Updated Phase II results from petosemtamab have impressed ahead of ASCO, outshining Keytruda monotherapy and its bispecific rival from Bicara.

Affimed’s ASCO ‘Hail Mary’ As Survival Chances Slim

 
• By Kevin Grogan

The German biotech has been forced into insolvency and NASDAQ suspension.

TIL The CARs Come Home: How Cell Therapy’s Solid Tumor Future Is Shaping Up

 
• By Alaric DeArment

Iovance’s Amtagvi won FDA accelerated approval in February, and Adaptimmune’s afami-cel may not be far behind, but cell therapies for solid tumors come with some extra challenges.

More from Conferences

Sanofi R&D Head’s Words Of Wisdom For Biotechs

 
• By Kevin Grogan

Houman Ashrafian tells delegates at Swiss Biotech Day that ‘literally only two things matter in our industry – target credentialing and differentiated pharmacology. The rest is execution.’

Switzerland Biopharma To Stay Strong Despite More Cash Going To US And China

 
• By Kevin Grogan

The sector is continuing to show resilience despite financial and market challenges.

Stock Watch: Disappointing ACC Share Price Reactions For AstraZeneca And Lilly

 
• By Andy Smith

The end of the American College of Cardiology conference was a prelude to a volatile trading week for most stocks. Even before Liberation Day, reactions to the conference announcements were not encouraging.