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Earlier Use of Exelixis/Ipsen's Cabozantinib Hits Hurdle In Liver Cancer

Top-line COSMIC-312 Results

 
• By John Davis

Exelixis/Ipsen’s novel combination of cabozantinib and atezolizumab has produced mixed top-line results from the Phase III COSMIC-312 study, and although the companies are pressing ahead with further analyses, the doublet may struggle to compete in the first-line advanced liver cancer setting.  

liver cancer
PFS But Not OS Improved In Liver Cancer • Source: Alamy

The steady march of Exelixis, Inc./Ipsen SA’s oral tyrosine kinase inhibitor cabozantinib (Cabometyx), into earlier lines of cancer therapy may not happen in hepatocellular carcinoma, following disappointing overall survival (OS) results seen in an interim analysis of the ongoing COSMIC-312 Phase III study where it was used in combination with Roche Holding AG’s Tecentriq (atezolizumab). 

The analysis suggests that other combinations, including atezolizumab with bevacizumab (Roche’s Avastin and generics), may retain a leading position in...

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