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BI/Lilly's Jardiance Crowned As Heart Failure Game Changer After EMPEROR-Preserved

'Unequivocal Benefit' Unveiled At ESC

 
• By Kevin Grogan

The full dataset from the closely-watched study demonstrated that Jardiance showed a 21% reduction in the risk of cardiovascular death or hospitalization for HFpEF compared with placebo, a significantly greater benefit than seen with the only approved drug for the indication, Novartis's Entresto.

Heart

Adjectives such as ground-breaking and game-changing have greeted the detailed results of the closely watched EMPEROR-Preserved trial of Boehringer Ingelheim GmbH and Eli Lilly and Company's Jardiance, with investigators stating that the SGLT2 inhibitor is the first drug to show "unequivocal benefit" on major harmful outcomes in patients with heart failure and a preserved ejection fraction (HFpEF).

The results from the 5,988-patient study, the highlight of the virtual European Society of Cardiology meeting, showed that Jardiance (empagliflozin) plus standard of care demonstrated a 21% reduction for the composite primary endpoint of cardiovascular death or hospitalization in adults with HFpEF compared with placebo plus SOC

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