Evotec CSO: BMS Opt In On CNS Compound ‘Augurs Well’ For Discovery Pact

Brings Bristol Myers Additional Program Rights In Neurodegenerative Diseases.

Further promising compounds will be explored after Bristol Myers Squibb exercised its option to enter an exclusive license for Evotec’s investigational EVT8683, generated by the German group’s iPSC platform as a potential treatment for neurodegenerative conditions.

EVT8683 is the CNS discovery alliance’s most advanced program • Source: Alamy

It took less than five years for a CNS drug discovery pact between Evotec SE and Bristol Myers Squibb Company using the German pharma’s novel iPSC platform to bring its first compound to the verge of clinical testing in humans, and further candidates are likely to emerge shortly from the alliance.

More from Business

More from Scrip

Roche’s Brain Shuttle Delivers In Alzheimer’s, Moves Ahead To Phase III

 

By allowing it to enter the brain more easily, trontinemab’s brain shuttle brings more patients to ‘amyloid zero’ levels faster, and with fewer brain swelling side effects.

Compass’ Bispecific BTC Contender Meets Phase II/III Endpoint

 
• By 

Compass' bispecific antibody tovecimig hits primary efficacy endpoint in Phase II/III top-line data in advanced biliary tract cancer, and may have class side-effect advantages. But additional survival data may be needed to support US approval.

AZ’s Oncology R&D Head On China’s Scientific Promise And True Innovation

 

AstraZeneca remains committed to investing in R&D and alliances in China, where Susan Galbraith, the UK major’s head of oncology R&D, sees innovation eventually reaching parity with the US and Europe.