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Vifor/Angion Collaboration On Rocky Ground As ANG-3777 Phase III Trial Fails In Kidney Transplant Patients

 
• By Ayisha Sharma

Vifor and Angion’s ANG-3777 has failed in a Phase III trial for kidney transplant patients at risk of delayed graft function less than a year after the companies sealed a $80m licencing deal for the product. As focus shifts to another rare nephrological indication, analysts express skepticism.    

Human kidney cross section on scientific background showing adrenal gland as well. 3d illustration
• Source: Shutterstock

Vifor Pharma Group and Angion Biomedica Corp.’s partnership for ANG-3777 has faced a major setback as the drug candidate missed the primary endpoint in a Phase III trial for its lead indication in kidney transplant patients at risk for developing delayed graft function (DGF), topline data show.

ANG-3777 is in a Phase II trial for another indication, cardiac-surgery associated acute kidney injury (CSA-AKI), but analyst expectations have cooled following the DGF flop

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