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Deciphera’s Qinlock Hits GIST Roadblock With Phase III Failure

 
• By Alaric DeArment

The drug remains likely to get approval in Europe, but for now stuck in fourth-line treatment. The company’s pipeline lacks other near-term catalysts.

Cancer cells on scientific background.3d illustration
Deciphera reported that the Phase III trial of Qinlock in second-line GIST did not reach its primary endpoint • Source: Shutterstock

Deciphera Pharmaceuticals, Inc.’s Qinlock (ripretinib) is stuck in the later lines of gastrointestinal stromal tumor (GIST) treatment for the foreseeable future following the failure of a Phase III trial to bring it into earlier lines, while the biotech itself looks set to enter a lull for a while in terms of pipeline catalysts.

The company announced topline results on 5 November from the 453-patient Phase III INTRIGUE study comparing Qinlock against Pfizer...

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