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Did MEI/Kyowa Kirin Beat The PI3K Tolerability Trap?

Zandelisib Shows Unexpectedly Positive Data

 
• By Alaric DeArment

PI3K-delta inhibitors have often suffered from safety and tolerability issues, but Phase II data show higher efficacy and lower discontinuation rates for zandelisib than others in the class.

Snails on the athletic track moves the finish line (By Sergey Lavrentev. Shutterstock 463225937)
MEI/Kyowa Kirin's zandelisib appears to pull ahead of other PI3K-delta inhibitors on efficacy and safety • Source: Shutterstock

New data suggest that Kyowa Kirin Co., Ltd./MEI Pharma, Inc.’s PI3K inhibitor zandelisib has better-than-expected efficacy data and a favorable safety profile that could position it as a top player in a class whose members have often suffered from safety issues.

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