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Yescarta, Breyanzi Offer Practice-Changing Options For Second-Line LBCL

Both CAR-Ts Offer Survival Gains, With Longer Data For Kite’s Product

 
• By Mandy Jackson

Data at ASH show CAR-T therapies may replace standard of care in an earlier line of large B-cell lymphoma with similar response rates and event-free survival for Kite’s established Yescarta and Bristol’s newer Breyanzi.

Game changer as a business creative metaphor art
After years with chemo and stem cell transplant as the only second-line option, CAR-T therapy offers a more effective solution • Source: Alamy

Phase III clinical trial results presented on 11 and 12 December at the American Society of Hematology (ASH) annual meeting for two CD19-targeting chimeric antigen receptor T-cell (CAR-T) therapies – Bristol Myers Squibb Company’s Breyanzi (lisocabtagene maraleucel) and Gilead Sciences, Inc. subsidiary Kite Pharma, Inc.’s Yescarta (axicabtagene ciloleucel) – are being hailed as practice-changing for adults with large B-cell lymphoma (LBCL) who were refractory or relapsed within 12 months of first-line treatment.

Each of the CAR-T products, both of which are approved after two or more prior lines of treatment, quadrupled event-free survival compared with the standard of care – salvage chemotherapy...

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