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Pfizer And AbbVie JAKs Finally Join Dupixent In US Atopic Dermatitis Space

Cibinqo And Rinvoq Offer Oral Alternative To Blockbuster

 
• By Kevin Grogan

The arrival on the US eczema market of a couple of oral JAK inhibitors with stellar data on itching could provide a challenge to Sanofi and Regeneron's blockbuster Dupixent. However, Pfizer and AbbVie will have to overcome dermatologists' fears about the class-effect safety warnings their drugs come with.

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Pfizer and AbbVie neck and neck after ezcema approvals on the same day • Source: Alamy

After months of delays, oral competition to Sanofi and Regeneron Pharmaceuticals, Inc.’s blockbuster Dupixent in the hot area of atopic dermatitis has finally arrived in the US with regulators giving the thumbs up to two JAK-1 inhibitors, AbbVie Inc.'s Rinvoq and Pfizer Inc.'s Cibinqo.

First up, the US Food and Drug Administration has approved 15mg and 30mg Rinvoq (upadacitinib) for moderate to severe atopic dermatitis in adults and children aged 12 and older whose disease did not respond to previous treatment and is not well controlled with other pills or injections

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