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Could Faricimab Data Help Roche Maintain Ophthalmic Market Foothold?

 
• By Alaric DeArment

The company published data for the bispecific antibody in wet AMD and DME, with non-inferior efficacy to Eylea and growing support for less frequent administration.

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Roche's Genentech published Phase III data for faricimab in wet AMD and DME • Source: Shutterstock

Roche Holding AG’s Genentech is looking to retain its position in the ophthalmology market as one of its leading products faces market erosion due to biosimilar competition while gene therapy competitors potentially gain ground as well. The publication of Phase III data for its bispecific antibody faricimab in wet age-related macular degeneration (AMD) and diabetic macular edema (DME) reinforces the drug’s market potential, particularly the possibility of less-frequent dosing resulting in fewer patients lost to follow-up.

Faricimab, a bispecific antibody targeting vascular endothelial growth factor-A (VEGF-A) and angiopoietin-2 (Ang-2), is under US Food and Drug Administration and European Medicines Agency review. The company announced results from YOSEMITE and RHINE in December 2020. (Also see "Roche’s Ophthalmic Bi-Specific Faricimab Still A DME Contender" - Scrip, 21 December, 2020

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