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Turning Point ROS1/TRK Inhibitor Repotrectinib Could Stand Out On Durability

 
• By Alaric DeArment

The drug showed a high durability of response in ROS1-positive NSCLC patients, a factor that could give it significant differentiation compared with approved agents.

Turning Point's repotrectinib showed a high level of durability of response • Source: Alamy

Turning Point Therapeutics Inc. has the chance to secure a piece of the market for ROS1-positive non-small cell lung cancer with its ROS1/TRK inhibitor, repotrectinib, after presenting positive Phase I/II data that showed efficacy in line with competitors, but with longer durability.

The company announced topline data by blinded independent central review (BICR) from the TRIDENT-1 trial

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• By Jessica Merrill

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First Win For AstraZeneca’s Enhertu In Early-Stage Breast Cancer Treatment

 
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Already dominating in later lines of breast cancer treatment, Enhertu could now displace both chemotherapy combinations and Roche’s Kadcyla in early-stage HER2-positive patients.

In Brief: Strong OS Results For Immutep’s Eftilagimod/Keytruda Combo In Head And Neck Cancer

 
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Australian firm's combo of eftilagimod and Keytruda shows 17.6-month median overall survival in first-line HNSCC patients with low PD-L1, raising hopes for potential accelerated approval.

In Brief: Positive New Data For Aptose’s Triplet Therapy In 1L AML

 
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• By Ian Haydock

Mid-sized Japanese pharma firm to acquire tobacco giant’s pharma operations and take private the listed Torii Pharmaceutical business, in bid to build sales reach and strengthen manufacturing.

Copycats Compound Novo’s Wegovy Growth Problems

 
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The US FDA has ordered compounders of the Danish firm's obesity drug semaglutide to shut up shop later this month, but competition from Eli Lilly is only increasing.

First Win For AstraZeneca’s Enhertu In Early-Stage Breast Cancer Treatment

 
• By Andrew McConaghie

Already dominating in later lines of breast cancer treatment, Enhertu could now displace both chemotherapy combinations and Roche’s Kadcyla in early-stage HER2-positive patients.