SpringWorks Targets Rare Tumors, But Myeloma Is The Mother Lode

The company aims to file for desmoid tumors in the second half of 2022, but it has more than half a dozen combination programs with BCMA-targeting therapies in multiple myeloma.

While SpringWorks is initially pursuing desmoid tumors, multiple myeloma represents a much bigger market • Source: Shutterstock

SpringWorks Therapeutics Inc. hopes to become the first company to win US Food and Drug Administration approval for a drug to treat desmoid tumors, a rare and potentially fatal cancer type, after a successful Phase III study of nirogacestat, and the company is already working on commercialization plans. But the drug may have a bigger opportunity as a combination treatment with cell therapy in multiple myeloma.

SpringWorks announced on 24 May that nirogacestat met the primary endpoint and was generally well tolerated in the Phase III...

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