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Ipsen’s Onivyde SCLC Dreams Die With Phase III Failure, Focus Shifts To Pancreatic

Stumble In Plans To Expand Label

 
• By Ayisha Sharma

The French firm’s Onivyde has missed the mark in an advanced small-cell lung cancer Phase III trial, prompting the firm to tout the drug’s prospects in a large pancreatic cancer indication instead.  

Image of an IV drip, often used in chemotherapy
Onivyde Is Being Studied In Combination With Traditional Chemotherapy Drugs • Source: Shutterstock

Ipsen SA’s Onivyde has flunked the Phase III RESILIENT trial in small-cell lung cancer, raising the stakes for an advanced pancreatic cancer study of the liposomal chemotherapy product set to read out later this year.

RESILIENT was studying Onivyde (irinotecan liposomal injection) against the chemotherapy topotecan (GlaxoSmithKline Pharmaceuticals Ltd

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Pipeline Watch: Six Approvals And Thirteen Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.

Viatris Will File ‘Fast-Acting’ Meloxicam For FDA Approval This Year

 
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Seven years after acquiring it, Viatris will seek approval of a meloxicam formulation for acute pain backed by data from two Phase III studies in post-surgical pain settings.

CRISPR Therapeutics Unveils Promising Early In Vivo Cholesterol-Lowering Results

 
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The Phase I results are the best to date among ANGPTL3-targeting candidates in the pipeline, but analysts will wait for further updates before predicting a likely winner.

Sanofi R&D Head’s Words Of Wisdom For Biotechs

 
• By Kevin Grogan

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Sanofi R&D Head’s Words Of Wisdom For Biotechs

 
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Marea Eyes Cardioprotective Benefit With ANGPTL4 Inhibition

 
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First Win For AstraZeneca’s Enhertu In Early-Stage Breast Cancer Treatment

 
• By Andrew McConaghie

Already dominating in later lines of breast cancer treatment, Enhertu could now displace both chemotherapy combinations and Roche’s Kadcyla in early-stage HER2-positive patients.