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Aptinyx Appears To Be Moving On From Pain With Fibromyalgia Miss

 
• By Joseph Haas

Lead candidate NYX-2925 has failed a pair of Phase IIb studies in diabetic peripheral neuropathy and now one in fibromyalgia, leaving Aptinyx’s likely last hopes in neuropsychiatric indications.

nerve cells, concept for neurodegenerative and neurological disease
Another setback in chronic pain leaves Aptinyx focusing on PTSD, dementia

Aptinyx, Inc. is likely staking out a new direction for its N-methyl-D-aspartate (NMDA) modulator programs now that NYX-2925 has failed a third study in a chronic pain indication. The Chicago-area biotech told Scrip on 12 August that while it has not formally pulled the plug on the candidate following failures in diabetic peripheral neuropathy and fibromyalgia, its focus going forward will be on two other mid-stage NMDA modulators for post-traumatic stress disorder and cognitive impairment related to dementia.

Analysts said they were not surprised by the failure of NYX-2925 to hit the primary endpoint in the Phase IIb...

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IO Biotech Plans Cylembio Filing Despite ‘Narrowly Missed’ Phase III Endpoint

 
• By Mandy Jackson

The company plans to meet with the US FDA prior to submitting a BLA before the end of 2025 for its cancer vaccine as a first-line advanced melanoma treatment in combination with Keytruda.

Sjögren’s Success For Ianalumab Shores Up Novartis’s Pipeline-In-A-Product Plans

 
• By Alexandra Shimmings

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Pipeline Watch: Five Approvals And Two Phase III Readouts

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BeBetter, Trinomab Advance IPOs On China’s STAR Market In Firsts Since Policy Easing

 
• By Dexter Jie Yan

BeBetter becomes first unprofitable innovative drug maker to have application for an IPO on Shanghai's STAR Market cleared by China’s top securities regulator, while Trinomab becomes first among peers to have IPO filing accepted.

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Novartis’s ‘Pipeline-In-A-Product’ Assets Progressing Well

 
• By Kevin Grogan

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Vertex’s Pain Drug Failure Adds To Investor Doubts

 
• By Andrew McConaghie

A Phase II trial to develop a second NaV1.8 pain signal inhibitor for acute pain has failed and the US FDA has given a thumbs down on Journavx’s path to broader use in peripheral neuropathic pain.

Cardiff Pushes Towards Colorectal Cancer Phase III As Funding Questions Loom

 
• By Manas Mishra

Cardiff Oncology is open to going it alone, a partnership and even an exit as the San Diego, CA-based firm tries to push its PLK1 inhibitor through late-stage development.