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Aptinyx Appears To Be Moving On From Pain With Fibromyalgia Miss

 
• By Joseph Haas

Lead candidate NYX-2925 has failed a pair of Phase IIb studies in diabetic peripheral neuropathy and now one in fibromyalgia, leaving Aptinyx’s likely last hopes in neuropsychiatric indications.

nerve cells, concept for neurodegenerative and neurological disease
Another setback in chronic pain leaves Aptinyx focusing on PTSD, dementia

Aptinyx, Inc. is likely staking out a new direction for its N-methyl-D-aspartate (NMDA) modulator programs now that NYX-2925 has failed a third study in a chronic pain indication. The Chicago-area biotech told Scrip on 12 August that while it has not formally pulled the plug on the candidate following failures in diabetic peripheral neuropathy and fibromyalgia, its focus going forward will be on two other mid-stage NMDA modulators for post-traumatic stress disorder and cognitive impairment related to dementia.

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