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Poxel’s Pioglitazone Formulation Meets Key Endpoints In Phase II NASH Study

 
• By Joseph Haas

A version of the diabetes drug intended to reduce PPAR gamma activation shows hoped for benefits and safety in a Phase II study. Poxel will now choose to advance one of two mid-stage NASH candidates.

Tough choice
Poxel now must make a decision on which Phase II NASH drug to take forward • Source: Shutterstock

Cash-poor Poxel SA is drawing nearer to a key decision about which of its two mid-stage non-alcoholic steatohepatitis candidates to move into Phase III, but positive top-line data reported on 30 August from a Phase II study of PXL065, a proprietary candidate derived from established diabetes drug pioglitazone, appeared to further de-risk at least one of its options.

Poxel, which reported cash on hand of €16.1m (about $16.8m) at the end of the second quarter, is focusing on NASH and rare metabolic diseases despite last year’s approval in...

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