Amgen’s Lumakras Efficacy Confirmed In Phase III, But Not As Strong As Phase II

ORR 28% Versus 37% In Trial Prior To Accelerated Approval

Lumakras data at ESMO in KRAS G12C-mutated lung cancer bested docetaxel on PFS, and largely on safety. OS was better for chemotherapy, but the trial was not powered for statistical significance on OS.

lung cancer with cancer cell on the lung and magnifying glass
Responses to Lumakras came sooner and lasted longer than with docetaxel • Source: Shutterstock

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