AstraZeneca Pulls Plug On Ionis’ PCSK9 Candidate

While the Phase IIb SOLANO trial of ION449 met its primary endpoint, AstraZeneca had set a high bar of 70% LDL cholesterol reduction for competitiveness that the study did not hit.

AstraZeneca will not move Ionis PCSK9 candidate ION449 into Phase III after Phase IIb results did not meet its high efficacy bar • Source: Shutterstock

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