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AstraZeneca Pulls Plug On Ionis’ PCSK9 Candidate

 
• By Alaric DeArment

While the Phase IIb SOLANO trial of ION449 met its primary endpoint, AstraZeneca had set a high bar of 70% LDL cholesterol reduction for competitiveness that the study did not hit.

AstraZeneca will not move Ionis PCSK9 candidate ION449 into Phase III after Phase IIb results did not meet its high efficacy bar • Source: Shutterstock

Ionis Pharmaceuticals, Inc. has found its hopes of competing in the PCSK9 inhibitor field dashed as partner AstraZeneca plc has chosen not to move ION449 into Phase III development because it did not think it would be competitive against Novartis AG’s Leqvio (inclisiran).

Ionis announced on 23 September that the Phase IIb SOLANO study of ION449, also known as AZN8233, administered at 60mg...

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