Galecto Validates LOXL2 Targeting With Interim Myelofibrosis Phase II Success

30 Sep 2022

• By Ayisha Sharma

The US biotech’s LOXL2 inhibitor candidate has reduced collagen fibrosis of the bone marrow in a small number of Phase II patients, helping validate a historically tricky approach attempted by few.

Row of ticks — Galecto's Drug Is First In Class In The Pipeline • Source: Shutterstock

Galecto Inc.’s GB2064 has shown positive interim efficacy in the Phase IIa MYLOX-1 trial in myelofibrosis, giving weight to the inhibition of LOXL2 as an effective therapeutic strategy for the disease despite the target having little pipeline activity.

MYLOX-1 trial is evaluating twice-daily 1000mg doses of GB2064 in 21 myelofibrosis patients who are ineligible, refractory to or intolerant of treatment with a Janus kinase (JAK) inhibitor for nine...

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In Brief: Nicox Extends Cash Runway As Kowa Advances NCX 470 In Japan

29 May 2025

• By Sushmita Panda

Eye drug is already in Phase III trials elsewhere, with results due in Q3. Nicox could earn up to a further €24.5m in milestones and royalties from Kowa alliance.

GSK’s Bet On Spero’s Oral cUTI Antibiotic Poised To Pay Off With New Phase III Data

28 May 2025

• By Joseph Haas

Spero and partner GSK have Phase III non-inferiority data to support approval of tebipenem as the first oral antibiotic for complicated urinary tract infections.