Arvinas And Pfizer’s Protein Degrader Shows Mixed Results In Breast Cancer

Data Accidentally Released Ahead Of Congress

The frontrunner in the new protein degrader class has shown lackluster Phase II results in breast cancer, but Arvinas hopes for success in less heavily pre-treated patients in Phase III.

Protein degradation
Arvinas is a leader in the field of protein degradation. • Source: Shutterstock

Arvinas and Pfizer’s ARV-471 is seen as the leading molecule in a new class of protein degrader drugs, and as such, its results in a Phase I/II study in metastatic breast cancer have been keenly awaited.

However, new data released from the Phase II single-arm VERITAC expansion cohort study in heavily pre-treated patients with locally advanced...

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