Early Data On Amgen’s AMG 133 Show Potential Durability, Dosing Advantage In Obesity

The drug is dosed once every four weeks – compared with Mounjaro and Wegovy’s weekly dosing – but the company also signaled it is considering extended dosing intervals.

Amgen announced data on AMG 133 in obesity • Source: Shutterstock

It’s still early days, but the first set of data on Amgen, Inc.’s bispecific glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist and glucagon-like peptide-1 (GLP-1) receptor agonist molecule, AMG 133, suggest it could gain an advantage on the market with its efficacy, durability and less frequent dosing in treating obesity than competing drugs.

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