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AstraZeneca/Daiichi Sankyo’s Next ADC Shows Promise In Triple-Negative Breast Cancer

Aiming To Overhaul Gilead’s Trodelvy

 
• By Andrew McConaghie

Having established Enhertu as their first antibody-drug conjugate blockbuster, AstraZeneca and Daiichi Sankyo are looking to challenge Gilead in the TROP2-targeting field as well.

AstraZeneca
AstraZeneca and Daiichi Sankyo are looking to repeat the success seen with Enhertu • Source: Shutterstock: Elzbieta Krzysztof

AstraZeneca and Daiichi Sankyo could have another antibody-drug conjugate (ADC) winner on their hands, with promising results from two early studies in triple-negative breast cancer.

The companies have scored a major hit with their HER2-targeting Enhertu (trastuzumab deruxtecan) and are now following up with datopotamab...

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