1. Scrip
  2. >>R&D
  3. >>Clinical Trials

Astellas Reports Second Phase III Win With Zolbetuximab In Stomach Cancer

 
• By Joseph Haas

The anti-Claudin-18.2 agent plus chemotherapy improves progression-free survival in inoperable or metastatic stomach cancer, following a similar Phase III readout in November.

Astellas
Astellas now has two succesful Phase III readouts for zolbetuximab • Source: Shutterstock

Astellas Pharma, Inc. has posted its second positive Phase III trial readout for its first-in-class Claudin-18.2 antibody therapy in stomach cancer, moving a candidate the Japanese pharma has called vital to its strategy in gastric cancer treatment closer to filing for approval globally. Zolbetuximab (IMAB362) has met the primary endpoint of progression-free survival (PFS) as well as an overall survival secondary endpoint in the Phase III GLOW trial, Astellas reported on 16 December.

The primary asset in Astellas’s 2016 buyout of Germany’s Ganymed Pharmaceuticals AG for €422m, zolbetuximab is being tested in Claudin-18.2-positive, HER2-negative, locally advanced inoperable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. If approved, it would compete with Bristol Myers Squibb Company’s anti-PD-1 agent Opdivo (nivolumab) in first-line, HER2-negative stomach cancer

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

  • Start your 7-day free trial
  • Explore trusted news, analysis, and insights
  • Access comprehensive global coverage
  • Enjoy instant access – no credit card required
Start Free Trial

Already a subscriber?

More from Clinical Trials

Marea Eyes Cardioprotective Benefit With ANGPTL4 Inhibition

 
• By Joseph Haas

Phase IIa data for ANGPTL4-targeted antibody shows reduced triglycerides and remnant cholesterol, which Marea asserts indicates potential to protect against cardiovascular outcomes.

First Win For AstraZeneca’s Enhertu In Early-Stage Breast Cancer Treatment

 
• By Andrew McConaghie

Already dominating in later lines of breast cancer treatment, Enhertu could now displace both chemotherapy combinations and Roche’s Kadcyla in early-stage HER2-positive patients.

In Brief: Strong OS Results For Immutep’s Eftilagimod/Keytruda Combo In Head And Neck Cancer

 
• By Sushmita Panda

Australian firm's combo of eftilagimod and Keytruda shows 17.6-month median overall survival in first-line HNSCC patients with low PD-L1, raising hopes for potential accelerated approval.

In Brief: Positive New Data For Aptose’s Triplet Therapy In 1L AML

 
• By Sushmita Panda

Aptose’s tuspetinib triplet shows early mutation-agnostic promise in new data from Phase I/II program for frontline acute myeloid leukemia.

More from R&D

Chinese Firms Build Obesity Clinical Pipeline But Face Wider Hurdles

 
• By Xu Hu

Despite the ability to initiate clinical trials quickly and having strong manufacturing capacity, Chinese companies are facing multiple challenges in the obesity space.

Aldeyra Plans To File Reproxalap Again With New Dry Eye Symptom Data

 
• By Joseph Haas

The biotech hopes a third time will be the charm after two FDA complete responses, with plans to position its eye drop as offering quicker onset of action.

Lilly And Alchemab Tap Into Resilient Individuals To Develop ALS Drug

 
• By Andrew McConaghie

The pharma company is helping to validate the biotech’s model by developing a novel amyotrophic lateral sclerosis candidate, based on its novel approach that ‘turns drug discovery on its head’.