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Ionis Enters $500m+ Agreement With Royalty Pharma To Help Fund Late-Stage Pipeline

Including Wholly Owned Assets

 
• By Ayisha Sharma

The US firm has sold some of its royalty stream for the gene therapy Spinraza and cardiovascular drug candidate, pelacarsen, to Royalty Pharma for $500m upfront, which should help fund upcoming milestones for Ionis’ late-stage pipeline.  

Animated image of green wads of money and gold coins on purple background
Ionis Needs The Cash To Advance Its Late-Stage Pipeline • Source: Shutterstock

Ionis Pharmaceuticals, Inc. has clinched a royalty agreement with Royalty Pharma plc covering Spinraza (nusinersen) and cardiovascular disease candidate pelacarsen for $500m upfront, extending its cash runway as it prioritizes its late-stage pipeline which includes some promising wholly owned assets.

Under the terms of the agreement, Royalty Pharma will receive 25% of the firm’s Spinraza royalty payments from Biogen, Inc. through to 2027 – increasing to 45% in 2028 – for up to $1.5bn in annual sales

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