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Protagonist/J&J Explore Autoimmune FRONTIER With Positive Psoriasis Results

 
• By Alaric DeArment

While full data are not yet available, JNJ-2113 would be the first oral drug against IL-23R, setting up for potential competition against oral TYK2 and IL-17-targeting drugs.

Protagonist announced Phase IIb data for an oral IL-23R antagonist partnered with J&J • Source: Shutterstock

Depending on how the data turn out, the Phase IIb FRONTIER 1 study of Protagonist Therapeutics, Inc. and Johnson & Johnson subsidiary Janssen Biotech Inc.’s interleukin-23 receptor (IL-23R) antagonist, JNJ-2113, suggests the drug could have a competitive edge against those with the same target thanks to its oral availability in patients with moderate-to-severe plaque psoriasis. The results also set it up as a potential competitor to oral TYK2 and IL-17 inhibitors.

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