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Karuna Three-For-Three As Another KarXT Schizophrenia Trial Hits Primary Endpoint

 
• By Alaric DeArment

The company is on track for a mid-2023 FDA filing, while executives suggested that they would likely pursue partnership for commercialization of the drug in Europe.

Karuna announced results of a third positive study of KarXT in schizophrenia • Source: Shutterstock

Karuna Therapeutics, Inc. has posted positive results from a third clinical trial of KarXT (xanomeline-trospium) in adults with schizophrenia with the announcement that the Phase III EMERGENT-3 trial met its primary endpoint of showing a meaningful reduction in the Positive and Negative Syndrome Scale (PANSS) score. The data indicate the drug should see commercial success, with analysts deeming its efficacy comparable to prior antipsychotics but with a differentiated side effect profile.

Karuna announced the results on 20 March, making EMERGENT-3 the third trial in the EMERGENT program and the second in Phase III to produce positive results, following the Phase II EMERGENT-1 study and the Phase III EMERGENT-2 trial

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