Cytokinetics, Inc. searched for a glimmer of hope with amyotrophic lateral sclerosis (ALS) candidate reldesemtiv for years, but has now given up on the drug after a data monitoring committee found no signs of efficacy in an interim look at the Phase III COURAGE-ALS study. The company said on 31 March that it will terminate the trial and all dosing of reldesemtiv, a fast skeletal muscle troponin activator, including among patients in a Phase III open-label extension study.
Cytokinetics’ Failure In ALS Clears Way For Focus On Aficamten
With a data monitoring committee finding no signs of efficacy in a Phase III trial of ALS candidate reldesemtiv, Cytokinetics can conserve cash and center on aficamten for hypertrophic cardiomyopathy.
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A decision from the FDA is due by 28 September.