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J&J Rybrevant Update Could Bode Positively For AstraZeneca’s Tagrisso

 
• By Jessica Merrill

A Phase III trial of Rybrevant with lazertinib versus Tagrisso in first line EGFR-positive NSCLC is continuing after an interim analysis, surprising some investors who thought it might be stopped early for efficacy.

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Investors questioned the meaning behind a Rybrevant trial continuing to a final analysis • Source: Shutterstock

Johnson & Johnson’s ambition to position a combination regimen of the bispecific antibody Rybrevant (amivantamab) and EGFR inhibitor lazertinib as superior to AstraZeneca PLC’s Tagrisso (osimertinib) for certain types of non-small cell lung cancer (NSCLC) seems uncertain after the company said a Phase III clinical trial testing the two regimens head-to-head passed an interim analysis without stopping for efficacy or safety.

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