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AstraZeneca’s IBD Hopes Deflated Amid Evolving Market And Pipeline Competition

Says Goodbye To Brazikumab

 
• By Ayisha Sharma

The major’s attempt to break into Crohn’s disease and ulcerative colitis has been cut short as a highly competitive market and pipeline, intensified by the entrance of biosimilars, renders further development of brazikumab impractical.  

Key Takeaways:

  • Brazikumab is being dropped due to the evolving competitive landscape and delays to its timeline.

  • IL-23 targeting drugs already on the market for IBD will soon face pressure from Humira biosimilars.

  • AstraZeneca has a separate asset in development for Crohn’s that recently entered a Phase I trial.

AstraZeneca PLC has discontinued its anti-IL-23 monoclonal antibody, brazikumab, for inflammatory bowel diseases (IBD) as the market and pipeline become increasingly crowded

The development plan for brazikumab comprised the Phase IIb/III INTREPID trial in Crohn’s disease and the Phase II EXPEDITION trial in ulcerative colitis (UC) and their respective open-label extensions

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