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AstraZeneca’s Dato-DXd Falls Short Of Great Expectations In Lung Cancer Study

Share Price Drops 7% On News

 
• By Andrew McConaghie

AstraZeneca’s Dato-DXd looks to have so far failed to add a ‘clinically meaningful’ benefit over chemo in the TROPION-Lung01 study, but analysts still expect success for the investigational antibody-drug conjugate.

AstraZeneca
• Source: Shutterstock: Elzbieta Krzysztof

AstraZeneca and Daiichi Sankyo’s goal of transforming non-small cell lung cancer treatment with their antibody-drug conjugate datopotamab deruxtecan (Dato-DXd) is looking harder to achieve after a first Phase III readout suggested results have fallen short of a best-case scenario in safety and efficacy.

The companies’ TROPION-Lung01 Phase III trial has been one of the year’s most eagerly awaited readouts, and pits the TROP2-targeted ADC against docetaxel, the current standard of care chemotherapy, in patients with locally advanced or metastatic

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