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Don’t Stop Relieving: Journey’s DFD-29 Trounces Oracea In Reducing Rosacea Lesions

 
• By Alaric DeArment

The company posted positive topline results from the Phase III MVOR-1 and MVOR-2 trials comparing DFD-29 against Galderma’s drug in papulopustular rosacea.

Journey announced topline results from two Phase III rosacea trials • Source: Shutterstock

Journey Medical Corp.’s DFD-29, partnered with Dr. Reddy's Laboratories Ltd., has potential to claim a significant share of the papulopustular rosacea market, which Galderma S.A.’s Oracea (doxycycline) currently dominates, having originally won US Food and Drug Administration approval in 1967. Topline results from Phase III clinical trials showed a statistically significant efficacy advantage for the drug over both Oracea and placebo in terms of reducing lesion count in adult patients with the skin condition.

Journey announced results from the MVOR-1 and MVOR-2 trials on 11 July, stating that both achieved their co-primary endpoints of investigator’s global assessment (IGA) of treatment success compared to placebo and total inflammatory lesion count compared to placebo,

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Pipeline Watch: Six Approvals And Thirteen Phase III Readouts

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• By Kevin Grogan

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• By Andrew McConaghie

Already dominating in later lines of breast cancer treatment, Enhertu could now displace both chemotherapy combinations and Roche’s Kadcyla in early-stage HER2-positive patients.