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Merck’s Keytruda Further Entrenches Women’s Oncology Position With Cervical Cancer Results

 
• By Alaric DeArment

Merck said the KEYNOTE-A18 trial in newly diagnosed, high-risk locally advanced patients met its PFS co-primary endpoint, while results for the OS endpoint were not yet mature.

Merck announced results from the Phase III KEYNOTE-A18 study in cervical cancer • Source: Shutterstock

Merck & Co., Inc. stands to expand its lead among PD-1 and PD-L1 checkpoint inhibitors in cancers affecting women with new interim Phase III results for Keytruda (pembrolizumab) in newly diagnosed, high-risk locally advanced cervical cancer, given the checkpoint inhibitor’s existing approvals in cervical cancer indications as well as in other gynecological cancers.

Without disclosing data, Merck announced on 19 July that in the KEYNOTE-A18 trial, Keytruda combined with external beam radiotherapy (EBRT)...

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Schrödinger Drops CDC7 Inhibitor SGR-2921 After Two Patient Deaths

 
• By Alaric DeArment

The drug is one of multiple candidates in the class that have been pulled from development, though it is not the company’s lead candidate.

Vedanta’s Live Bacteria Reach A Dead End In Ulcerative Colitis

 
• By Andrew McConaghie

The microbiome-based company’s trial of VE202 in ulcerative colitis has failed in Phase II, but its ongoing Phase III study in C difficile infection is more promising.

Xenon Nears Phase III Readout For Potential Epilepsy And Depression Blockbuster

 
• By Andrew McConaghie

Leading a field of rival potassium channel modulators, azetukalner will have a pivotal epilepsy readout early next year, with Phase III trials in depression and biopolar disorder also underway.

Another Day Another Win For Novartis’s Ianalumab – This Time In ITP

 
• By Aakash Babu

The Swiss drugmaker’s BAFF-R inhibitor and ADCC-mediated B-cell depletor candidate has chalked up another win in late-stage development, further strengthening its pipeline-in-a-product bid.

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Another Day Another Win For Novartis’s Ianalumab – This Time In ITP

 
• By Aakash Babu

The Swiss drugmaker’s BAFF-R inhibitor and ADCC-mediated B-cell depletor candidate has chalked up another win in late-stage development, further strengthening its pipeline-in-a-product bid.

Pfizer/Astellas’s Padcev Scores First Big Win In Bladder Cancer Study

 
• By Alaric DeArment

The drug, combined with Merck’s Keytruda, was successful among certain chemotherapy-ineligible MIBC patients, with another Phase III readout expected by March 2026.

IO Biotech Plans Cylembio Filing Despite ‘Narrowly Missed’ Phase III Endpoint

 
• By Mandy Jackson

The company plans to meet with the US FDA prior to submitting a BLA before the end of 2025 for its cancer vaccine as a first-line advanced melanoma treatment in combination with Keytruda.