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In Alnylam’s Search For A Mass-Market Treatment, A Twice Yearly Blood Pressure Injection Could Fit The Bill

Crucial Phase II Readouts This Year

 
• By Andrew McConaghie

Alnylam is using its RNA interference technology to target hypertension, which could create a true mass-market cardiovascular blockbuster drug for the firm – but upcoming Phase II data will need to be compelling.

Alnylam building
• Source: Alamy

Alnylam is recognized as a pioneer of the RNA interference (RNAi) gene-silencing field, but so far it has not been able to produce an out-and-out blockbuster from its innovative platform, instead having to fight it out in a competitive and niche ATTR amyloidosis market with drugs such as OnPattro (patisiran).

The Cambridge, MA-based biotech is, however, looking to broaden the range of its RNAi medicines, and its potential twice-yearly injection to treat high blood pressure,

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