Sage Therapeutics, Inc./Biogen, Inc.’s GABA-a receptor positive allosteric modulator, zuranolone, has won US Food and Drug Administration approval for postpartum depression (PPD) under the brand name Zurzuvae, but a rejection in major depressive disorder (MDD) has surprised analysts and significantly dampened sales potential.
Reprioritization On Cards After Sage/Biogen’s Zurzuvae Receives CRL For MDD
Despite PPD Approval
The firms’ Zurzuvae has become the first oral drug to win US approval for postpartum depression but a thumbs down in the larger major depressive disorder indication has raised concerns that Biogen could pull out of the partnership as Sage turns its efforts to cutting costs.
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