Exelixis, Inc. got its second bit of good news in the space of a week with positive results from a pivotal trial of Cabometyx (cabozantinib) in pancreatic and extra-pancreatic neuroendocrine tumors (NETs), following closely the announcement of success in a study of the same drug in prostate cancer. On the other hand, while the NETs indication is one of significant unmet need, it may be relatively small in terms of revenue potential.
The company announced 24 August that the data and safety monitoring board (DSMB) of the National Cancer Institute-sponsored and Alliance for Clinical Trials in Oncology-led Phase III CABINET trial unanimously recommended unblinding the study early due to a “dramatic” improvement in efficacy for Cabometyx compared with placebo in patients with advanced pancreatic and extra-pancreatic NETs whose disease had progressed following prior systemic therapy
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