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AstraZeneca Looks To Challenge GSK’s Nucala With Fasenra EGPA Data

Head-To-Head Trial Of The Two IL-5 Inhibitors

 
• By Kevin Grogan

AstraZeneca's Fasenra has demonstrated non-inferiority compared with GSK's fellow interleukin-5 inhibitor Nucala for eosinophilic granulomatosis with polyangiitis and the company hopes its more convenient single monthly subcutaneous injection will win market share if approved for the rare, immune-mediated inflammatory disease.

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AstraZeneca goes head-to-head with GSK in EPGA • Source: Shutterstock

AstraZeneca PLC could soon have another indication to add to severe asthma for its respiratory blockbuster Fasenra after presenting data from a late-stage trial for eosinophilic granulomatosis with polyangiitis (EGPA).

The UK drugs major has posted positive high-level results from the MANDARA Phase III trial which show that Fasenra (benralizumab), an interleukin-5 inhibitor, demonstrated non-inferior rates of remission when compared...

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