With Madrigal Pharmaceuticals, Inc.’s resmetirom expected to become the first authorized therapy for non-alcoholic steatohepatitis (NASH), attention is growing for another class earlier in development, FGF21 analogs, which could provide benefit in the sickest patients, those with cirrhosis or diabetes. In interviews at the American Association for the Study of Liver Disease meeting, executives from the three leading companies tried to argue that their drug is best in class.
Who Will Emerge As Best In Class Of The FGF21 Analogs In NASH?
Akero hopes to begin Phase III study of efruxifermin this year, with 89bio working to enter Phase III with pegozafermin in 2024. But just behind them, Boston Pharmaceuticals thinks it has a convenience and immunogenicity edge.
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