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Pharvaris’s Oral HAE Prevention Data May Threaten BioCryst’s Orladeyo

 
• By Joseph Haas

The Swiss firm reported that its oral bradykinin B2 receptor antagonist reduced monthly hereditary angioedema attacks by 84.5% compared with placebo, suggesting biologic-like efficacy with an oral drug.

Oral vs injectable
Pharvaris hopes to compete with injectables and the other oral in HAE • Source: Shutterstock

Pharvaris B.V. reported Phase II data on 6 December for its oral candidate for hereditary angioedema that both it and analysts are saying suggest biologic-like efficacy with the convenience of oral therapy. The catch? Pharvaris needs to get a US Food and Drug Administration hold lifted before it can try to set up an end-of-Phase II meeting with the agency and initiate a Phase III program.

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